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KMID : 0644319980040010089
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Journal of Korean Oriental Oncology
1998 Volume.4 No. 1 p.89 ~ p.110
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Correlative Effects of Yookmijihwangtang(六味地黃湯) on the T helper cell count, Blood cAMP, Testosterone and Cortisol
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金榮權/Kim, Young-Kuen
柳逢夏/朴東源/柳基遠/Ryu, Bong-Ha/Park, Dong-Won/Ryu, Ki-Won
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Abstract
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Yookmijihwangtang has been widely used oriental herb prescriptions, which is healing some discuss that come from insufficiency of innate essence and deficiency of kidey Ki. the meaning of healing discusses tonification of insufficient innate essence and insufficient kidney Ki can be regarded as reinforcement of wholely power of keeping homeostasis, that is correlated with immuno-responsibility which protects subject from outer antigen to keep normal vital condition. This study was aimed to investigate correlative effects of Yookmijihw angtang water abstract on the RBC, WBC, blood CD4+ Theler cell count, blood testosterone, blood cAMP and blood cortisol.
40 Sprague-Dawley male rats were divided into 5 groups(Normal, Control, SampleⅠ, SampleⅡ, SampleⅢ), 6 animals in every group. Normal group was not treated anything, control group was administrated normal saline in the same desage of sample Ⅰ. 3 Sample groups were received some of Yookmijihwangrang water abstract at one time per 24 hours during 5 days in different dosage. Sample Ⅰ (1/3 10pack/ml), SampleⅡ (1/62pack/ml), SampleⅢ(1/2.4pack/ml).
After finishing treatment, all experimental svbjects were killed for blood sample on RBC, WBC, blood CD4+ T helper cell count, spleen CD4+ T helper cell count, axillary lymph node CD4+ T helper cell count. .blood cAMP, blood testosterone and blood cortisol. The results were as follows:
RBC and WBC were incrased in all sample groups. Blood CD4+ Thelper cell count(CD4+ T cell count in the blood/whole lymphocyte count in the blood ×100%) was Mormal 46.17±5.88. Control 44.50±4.37, Sample Ⅰ 53.00±2.28. Sample Ⅱ 53.83±3.87, SampleⅢ 52.17±2.93. By the 95% Duncan ANOVA all experimental groups(sampleⅠ, sampleⅡ, sampleⅢ) showed slight significant difference from Nornal and Control.
Blood cAMP(nmd/l) were Normal 1.12±0.17, Control 1.16±0.32, SampleⅠ 0.46±0.07, SampleⅡ 0.44±0.04, SampleⅢ 0.54±0.04 All cxperimental groups were signigicantly different from both Normal and Control groups(p<0.05).
Blood cortisol(m l/ml) were Normal 100.00±2.00, Control 90.00±4.00, Samplc Ⅰ 440.00±5.00, SampleⅡ 520.00±40.00, SampleⅢ 470
00±7.00, Blood cortisol of all experimental groups were signifieantly increased(p<0.05).
The results suggest that Yookmijihwangiang water abstract could be administrated to patienrts who have some diseases insufficient essence.
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